Table 1.
Short-term stability of hematologic parameters in frozen stored clinical whole blood samples (n = 53).
| Baseline | Day 15 (frozen sample) | Day 30 (frozen sample) | ||||||
|---|---|---|---|---|---|---|---|---|
| Parameter | n | Mean (SD) | Mean (SD) | CVA, % | ICC | Mean (SD) | CVA, % | ICC |
| WBC, 109/L | 52 | 7.7 (5.2) | 4.8 (3.4)b | 38.8 (31.3 to 46.2) | 0.68 (0.03 to 0.88) | 5.3 (4.0)b | 32.1 (26.0 to 38.3) | 0.79 (0.11 to 0.93) |
| RBC, 1012/L | 53 | 3.1 (0.7) | 2.5 (0.7)c | 16.0 (12.6 to 19.4) | 0.58 (−0.08 to 0.84) | 2.5 (0.7)c | 16.4 (14.1 to 18.7) | 0.68 (−0.06 to 0.91) |
| HGB, g/dL | 53 | 9.4 (2.1) | 9.3 (2.1) | 1.2 (0.6 to 1.8) | 0.99 (0.98 to 0.99) | 9.4 (2.1) | 0.8 (0.4 to 1.3) | 1.00 (0.99 to 1.00) |
| RBC, 1012/L | 53 | 3.1 (0.7) | 2.5 (0.7)c | 16.0 (12.6 to 19.4) | 0.58 (−0.08 to 0.84) | 2.5 (0.7)c) | 16.4 (14.1 to 18.7) | 0.68 (−0.06 to 0.91) |
| HCT, % | 53 | 29.1 (6.6) | 25.6 (7.5)a | 11.7 (8.1 to 15.2) | 0.69 (0.31 to 0.85) | 25.1 (8.3)b | 13.7 (11.2 to 16.3) | 0.76 (0.17 to 0.91) |
| MCV, fL | 53 | 93.8 (6.7) | 102.3 (9.1)c | 6.8 (5.5 to 8.1) | 0.31 (−0.06 to 0.59) | 100.0 (10.3)c | 6.7 (5.4 to 8.0) | 0.30 (0.02 to 0.53) |
| MCH, pg | 53 | 30.5 (2.9) | 38.5 (10.2)c | 15.0 (12.0 to 18.0) | 0.06 (−0.11 to 0.25) | 38.5 (6.2)c | 15.8 (13.6 to 18.1) | 0.18 (−0.09 to 0.47) |
| MCHC, g/dL | 53 | 32.4 (1.4) | 37.9 (10.0)c | 10.9 (7.8 to 14.1) | 0.00 (−0.20 to 0.23) | 38.8 (7.0)c | 13.3 (10.8 to 15.8) | 0.10 (−0.08 to 0.30) |
| PLT, 109/L | 53 | 187.1 (127.4) | 202.0 (131.1) | 15.2 (9.7 to 20.6) | 0.95 (0.91 to 0.97) | 236.8 (146.2) | 24.2 (15.5 to 33.0) | 0.58 (0.35 to 0.74) |
| RDW, % | 49 | 15.4 (2.4) | 26.7 (3.9)c | 37.7 (34.1 to 41.3) | 0.03 (−0.03 to 0.12) | 31.0 (13.5)c | 44.0 (39.1 to 49.0) | 0.00 (−0.10 to 0.14) |
| MPV, fL | 16 | 10.1 (0.8) | 12.2 (0.7)b | 13.6 (11.5 to 15.8) | −0.28 (−0.57 to 0.11) | 11.8 (1.0)c | 11.3 (8.6 to 14.1) | 0.21 (−0.11 to 0.54) |
ICC, intraclass correlation coefficient; RBC, red blood cell count; MCHC, mean corpuscular hemoglobin concentration; RDW, red cell distribution width.
a
P < 0.05 compared with baseline mean.
b
P < 0.01 compared with baseline mean.
c
P < 0.001 compared with baseline mean.