Fig 3. Preliminary experiment.

A: Time course of rotarod performance measured by walking time on a rotarod (cut-off 300 seconds). In the compression group, the walking time gradually started to decline from 4 weeks and showed a significant decrease at 7 weeks after surgery (P < 0.001: two-way ANOVA). The performance reached a plateau with a low duration of about 50 seconds after 15 weeks. B: Time course of forelimb grip strength. In the compression group, grip strength decreased at 1 week after surgery due to surgery, but gradually increased as body weight increased. However, grip strength gradually declined from 6 weeks, and showed a significant difference at 7 weeks after surgery (P < 0.0001: two-way ANOVA) After that, the strength continued to decrease gradually, reaching approximately 10.5 N at 26 weeks postoperatively.