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. 2019 Dec 10;14(12):e0226292. doi: 10.1371/journal.pone.0226292

Fig 3. Summarizes the hypothesis mechanism process of omentin-1 on insulin signaling cascade.

Fig 3

Fig 3 Schematic representation of the effects of omentin-1 on insulin signaling cascade that explain positive effects of these adipokines on glycemic control. Akt: protein kinase b; TNF-α: Tumor Necrosis Factor; AMPK: AMP activated protein-kinase; ZAG: Zinc-α2-glycoprotein; AS160: Akt substrate of 160 kDa; GLUT: glucose transporter; IRS: insulin receptor substrate; mTOR: mammalian target of rapamicin; PPAR-γ: peroxisome proliferator-activated receptor; AdipoR1: Adipo receptor1; PI3K: phosphatidylinositol 3-kinase; RAB-10: Ras-related protein RAB-10. Fig 1 is drawn by the KA, without any copyright disputes.