Fig 3. Wrist actigraphy measurements in pre-AD and controls.

Box whisker plots of (A) Actual sleep (%) and Sleep efficiency (%), (B) Relative Amplitude (RA), Interdaily Stability (IS), Intra-daily Variability (IV) for controls (black, n = 5) and pre-AD individuals (green, n = 7). Actual sleep (%) was calculated as total sleep time in minutes divided by assumed sleep time (total elapsed time between ‘Fell Asleep’ and ‘Woke Up’ times). Sleep efficiency was calculated by the percentage of total sleep time divided by time in bed. Pre-AD, pre-symptomatic Alzheimer’s disease.