Table 2.
Univariable and multivariable analysis of potential demographic risk factors for high-grade dysplasia or colorectal cancer
| Baseline | HR univariable | 95% CI | p-value | HR multivariable [final model] | 95% CI | p-value |
|---|---|---|---|---|---|---|
| Diagnosis | ||||||
| UC | 1 | |||||
| CD | 1.13 | 0.92–1.39 | 0.258 | - | - | - |
| IBD-U | 0.84 | 0.57–1.23 | 0.365 | - | - | - |
| Sex | ||||||
| Female | 1 | 1 | ||||
| Male | 1.38 | 1.15–1.67 | 0.001 | 1.33 | 1.10–1.60 | 0.003 |
| LGD diagnosis | ||||||
| Before 2001 | 1 | – | – | – | ||
| After 2000 | 1.12 | 0.93–1.36 | 0.237 | – | – | – |
| Academic centre | 1.26 | 0.99–1.62 | 0.063 | 1.37 | 1.07–1.76 | 0.012 |
| Age at first LGD | ||||||
| <55 years old | 1 | 1 | 1 | |||
| >55 years old | 1.72 | 1.44–2.05 | <0.001 | 1.73 | 1.44–2.06 | <0.001 |
| IND before LGD | 1.69 | 0.84–3.40 | 0.14 | – | – | NS |
UC = ulcerative colitis, CD = Crohn’s disease, IBD-U = IBD-unclassified, LGD = low-grade dysplasia, IBD = inflammatory bowel disease, IND = indefinite for dysplasia, NS = not significant.