Figure 1.

Analysis of phosphorylated-signal transducer and activator of transcription 3 (p-STAT3) breast cancer samples from 39 datasets. (A) Using the PAM50 classification model, patients were assigned to the main luminal breast cancer molecular subtypes: Luminal A and luminal B. Luminal A-type cancers were more likely to possess high p-STAT3 levels in comparison to luminal B-type cancers (Wilcoxon P=3e⁻⁶). (B) p-STAT3 gene expression signatures in publically available microarray datasets according to the PAM50 breast cancer subtype. Kruskal-Wallis P-value is shown (P<0.01⁻¹⁰).