. 2017 Nov 27;52(2):424–432. doi: 10.3892/ijo.2017.4212

Table III.

Prognostic value of p-STAT3 (immunohistochemistry) using univariate analysis.

	DFS		OS
	HR (95% CI)	P-value	HR (95% CI)	P-value
All
Tumour p-STAT3 ordinal^a	0.84 (0.68–1.04)	0.10	0.83 (0.63–1.08)	0.16
Tumour p-STAT3 binary (positive vs. negative)	0.72 (0.51–1.04)	0.08	0.75 (0.48–1.18)	0.21
Stroma p-STAT3 ordinal^a	0.85 (0.68–1.05)	0.13	0.88 (0.67–1.15)	0.34
Stroma p-STAT3 binary (positive vs. negative)	0.78 (0.55–1.08)	0.14	0.79 (0.52–1.21)	0.28
ER⁺/HER2−
Tumour p-STAT3 ordinal^a	0.80 (0.63–1.01)	0.06	0.83 (0.62–1.11)	0.22
Tumour p-STAT3 binary (positive vs. negative)	0.66 (0.44–0.98)	0.04	0.70 (0.43–1.15)	0.16
Stroma p-STAT3 ordinal^a	0.86 (0.67–1.09)	0.20	0.92 (0.68–1.22)	0.55
Stroma p-STAT3 binary (positive vs. negative)	0.75 (0.52–1.09)	0.13	0.82 (0.52–1.30)	0.39
ER⁺/HER2⁺
Tumor p-STAT3 ordinal^a	1.09 (0.66–1.80)	0.73	0.86 (0.40–1.85)	0.71
Tumor p-STAT3 binary (positive vs. negative)	1.33 (0.56–3.21)	0.52	1.34 (0.45–3.93)	0.60
Stroma p-STAT3 ordinal^a	0.86 (0.49–1.52)	0.61	0.78 (0.36–1.67)	0.52
Stroma p-STAT3 binary (positive vs. negative)	0.93 (0.41–2.12)	0.86	0.79 (0.27–2.34)	0.67

Ordinal indicates 4 categories for immunohistochemistry, i.e., 0, 0.1–10, 10.1–100, >100; bold font indicates statistical significance. p-STAT3, phosphorylated-signal transducer and activator of transcription 3; ER, estrogen receptor; DFS, disease-free survival; OS, overall survival.