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Rg3 induced apoptosis by inhibiting NF-κB signaling pathway with FUT4 downregulation. A375P cells were pretreated by FUT4 siRNA, Rg3 (75 μg/ml) or NF-κB inhibitor Bay 11-7082 (10 μM). Control, untransfected cells; Mock, cells transfected with vector. Western blot analysis of expression levels of FUT4, caspase-3, Bcl-2 and survivin.
