Table V.
Top 10 important pathways of upregulated miRNA in drug resistant cells from DIANA miRPath v.2.0.
| KEGG pathway | P-value | Genes | miRNAs | |
|---|---|---|---|---|
| 1 | ErbB signaling pathway (hsa04012) | 3.40E-23 | 45 | 18 |
| 2 | Long-term potentiation (hsa04720) | 2.63E-22 | 35 | 16 |
| 3 | Insulin signaling pathway (hsa04910) | 4.36E-20 | 59 | 17 |
| 4 | Prostate cancer (hsa05215) | 1.52E-19 | 41 | 15 |
| 5 | PI3K-Akt signaling pathway (hsa04151) | 1.93E-19 | 121 | 17 |
| 6 | Wnt signaling pathway (hsa04310) | 1.86E-18 | 66 | 16 |
| 7 | mTOR signaling pathway (hsa04150) | 5.12E-18 | 32 | 15 |
| 8 | Focal adhesion (hsa04510) | 2.89E-17 | 78 | 17 |
| 9 | Regulation of actin cytoskeleton (hsa04810) | 2.73E-15 | 79 | 17 |
| 10 | Neurotrophin signaling pathway (hsa04722) | 1.23E-13 | 50 | 17 |