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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Neuropharmacology. 2019 Aug 2;158:107732. doi: 10.1016/j.neuropharm.2019.107732

Figure 9 -. Y1 receptor internalization in vivo after spared nerve injury.

Figure 9 -

Rats received sham surgery or spared nerve injury (SNI), consisting in cutting the common peroneal and tibial nerves unilaterally. The development of mechanical hyperalgesia was followed for 14 days as responses to von Frey filaments in the hind paws ipsilateral (A) and contralateral (B) to SNI. Repeated measures 2-way ANOVA, A: time p<0.0001, SNI p = 0.0246, interaction p <0.0001; B: time p=0.12, SNI p=0.22, interaction p =0.29. C. On day 14, rats with sham surgery or SNI received no stimulation (“control”), clamping of the ipsilateral hind paw with a binder clip for 2 min (“clamp”), or rubbing of the ipsilateral hind paw (“rub”). Repeated measures 2-way ANOVA: stimulus/SNI p<0.0001, side p<0.0001, interaction p=0.0053. Holm-Sidak’s post-hoc tests: ** p<0.01, *** p<0.0001 compared with sham (A) or sham/control (C).