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. Author manuscript; available in PMC: 2019 Dec 10.
Published in final edited form as: Cell Rep. 2019 Nov 26;29(9):2570–2578.e5. doi: 10.1016/j.celrep.2019.10.073

Figure 4. Linking Distal MYB Enhancers to Blood-Associated Traits.

Figure 4.

(A) ERN sub-network highlighting hemoglobin genes as common secondary targets of enhancers across the genome.

(B) MYB-enh-3 exhibits DNase I hypersensitivity in CD34+ common myeloid progenitor cells. SNPs and associated traits are highlighted.

(C) Gene set enrichment analysis (GSEA) of the DEGs upon MYB-enh-3 knockdown. Genes upregulated are positively correlated with hematopoietic differentiation genes.

(D) Heatmap indicates the expression pattern of genes that are identified in (C). Several hematopoietic differentiation genes are indicated.

See also Figure S4.