Figure 2.

Longitudinal changes in HbA1c among matched dulaglutide initiators versus basal insulin initiators (MMRM).*Significant difference between dulaglutide versus basal insulin with p value <0.05. Results are from a mixed-effects model with repeated measurements (MMRM). Data represent least square mean ± 95% confidence limit. Baseline reflects HbA1c results obtained between (index date - 183 days) and (index date + 14 days); the value closest to index date was chosen if there were multiple values. 3/6/9/12 months reflects HbA1c results obtained between windows of ±45 days around index date +92/183/274/365 days, with the value closest to and prior to the anchor date chosen if there were multiple values. Point estimates are available in online supplementary appendix table 6.