Skip to main content
. 2019 Nov 26;8:e50276. doi: 10.7554/eLife.50276

Figure 6. WASL activation and its actin modulation are critical for EMCV virus infection.

(A) Schematic representation of different WASL domain truncations. Each truncation is indicated by amino acid position on the constructs. (B) FACS quantification of EMCV infection in WASL KO cells transduced with different WASL domain truncations. (C) Western blot detection of WASL domain truncation expression constructs in lentivirus transduced WASL KO cells. (D) CK-869 inhibition of EMCV infection on naïve A549 cells at 10 hr post infection at an MOI of 1. (B, D) Error bars represent standard deviation of three replicates. The data shown are representative of two independent experiments. *: p<0.05, **: p<0.01, ***: p<0.001, ****: p<0.0001.

Figure 6—source data 1. Source data for Figure 6B and D: FACS quantification of virus infected cells.

Figure 6.

Figure 6—figure supplement 1. WASL activation and its actin modulation are critical for EMCV virus infection.

Figure 6—figure supplement 1.

(A) FACS quantification of EMCV infection in WASL KO cells (without normalization) transduced with different WASL domain truncations. (B) CK-869 inhibition of EMCV infection on naïve A549 cells (without normalization) at 10 hr post infection at an MOI of 1. Error bars represent standard deviation of three replicates. The data shown are representative of two independent experiments. *: p<0.05, **: p<0.01, ***: p<0.001, ****: p<0.0001.