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. 2019 Nov 20;8:e48476. doi: 10.7554/eLife.48476

Figure 1. HLA nomenclature.

Figure 1.

(A) Description of an HLA type (allele) using current standard nomenclature. The first two digits typically correspond to the serological antigen. The third and fourth digits distinguish HLA types that differ by one or more missense variants. The fifth and sixth digits distinguish HLA types that differ by one or more synonymous variants. The seven and eight digits distinguish HLA types that differ by noncoding variants. (B) The location of the MHC region on chromosome 6 (left). The 8.1 ancestral haplotype (8.1AH) is comprised of six HLA types (corresponding to six HLA genes) typically reported at four-digit resolution (middle). For each of the six HLA genes, we identified one to three eight-digit resolution HLA types that can be collapsed into their 8.1AH four-digit counterparts (right).