Table I. Terms and their definitions.

Term	Definition
Primary Outcome	Peanut threshold or lowest observed adverse effect level (LOAEL) which is the lowest cumulative dose causing an objective allergic reaction. Determined for each individual in mg peanut protein following each challenge
Primary Analysis	Difference in log-threshold between non-intervention challenge and each intervention challenge also expressed as percentage change
Secondary outcome	Eliciting dose (EDx) or population threshold cumulative eliciting dose (ED) predicted to provoke a reaction in a defined proportion of the population (x)
Full analysis population	Individuals who received at least one post baseline intervention challenge
Extended analysis population	All individuals who received a baseline peanut challenge
Baseline challenge	Initial double-blind placebo-controlled challenge to confirm diagnosis of peanut allergy
Non-intervention challenge	Open challenge to determine threshold when no intervention applied
Intervention challenge	Open challenge to determine threshold with either exercise or sleep deprivation intervention