Figure 6.
Gatifloxacin dose versus probability of favorable outcome in tuberculous meningitis. A, Plot of probability of gatifloxacin dose (mg/kg) versus survival based on relapse- and disability-free survival in 15 patients treated with 400mg of gatifloxacin for tuberculous meningitis. Any neurological disability was taken as a poor outcome, regardless of severity, as were death and relapse. B, Plot of probability of survival versus dose in mg/kg. In both cases, confidence intervals for the EC50 were too wide to be able to calculate an optimal dose with precision.