TABLE 4.
Source, clonal complex, sequence-, spa-, SSCmec-, and agr-types and virulence profiles of S. aureus isolated from different parts of India.
| Source (isolate number) | CC/ST, spa-type | SCCmec type | agr type | pvl gene | icaA/icaD | Serotypes | Virulence pattern |
| MRSA (n = 32) | |||||||
| Wound infection (2095) | 239/239, t037 | III | 1 | – | +/+ | II | sei-cna-hla-hlg-efb |
| Wound infection (2103) | +/+ | IV | sea-sei-cna-hla-hlg-efb | ||||
| Wound infection (2656) | 239/239,t037 | UT6 | 1 | – | +/+ | IV | sea-sei-cna-hla-hlg-efb |
| Wound infection (22/248) | +/+ | III | sea-cna-hla | ||||
| Wound infection (UC650) | +/+ | IV | sea-cna-hla-hlg-efb | ||||
| Wound infection (UC858) | −/− | V | sea-hla-hlg-efb | ||||
| Wound infection (UC1079) | 239/239,t2952 | UT6 | 1 | – | +/+ | I | sea-sei-cna-hla-hlg-efb |
| Wound infection (2658) | 239/241,t037 | UT6 | 1 | – | +/+ | IV | sei-cna-hlg-efb |
| Eye infection (P844628, N307002) | 239/239, t037 | UT6 | 1 | – | +/+ | IV | sei-cna-hla-hlg |
| ± | |||||||
| Eye infection (P853836) | 239/239, t037 | UT6 | 1 | – | ± | V | sea-cna-hla-hlg-efb |
| Wound infection (2380,2452) | 772/772, t657 | V | None | + | +/+ | VI | sea-sec-sei-cna-hla-hlg-efb |
| +/+ | |||||||
| Wound infection (UC609) | 772/772, t657 | V | 2 | + | +/+ | VI | sea-sec-sei-cna-hla-hlg-efb |
| Wound infection (22/252) | 772/Unk, t657 | V | None | + | −/− | VI | sea-sec-sei-cna-hla-hlg-efb |
| Eye infection (845) | 772/772, t345 | V | 3 | + | −/+ | I | sea-sec-sei-cna-hla-hlg-efb |
| Eye infection (1295) | 2884/88, t2526 | V | 2 | + | +/+ | III | sei-hla-hlg-efb |
| Eye infection (1690) | 5/5, t442 | V | 1 | – | +/+ | IV | sei-hla-hlg-efb |
| Eye infection (1820) | 772/772, t657 | V | 1 | + | +/+ | VII | sea-sec-sei-cna-hla-hlg-efb |
| Unknown (1189) | 772/772, t657 | V | 2 | + | +/+ | VI | sec-sei-cna-hla-hlg-efb |
| Unknown (1192,1249) | 772/772, t345 | V | 2 | + | +/+ | VII | sea-sei-cna-hla-hlg-efb |
| +/+ | VI | sec-sei-cna-hla-hlg-efb | |||||
| Unknown (2654) | 772/772, t345 | V | 1 | + | +/+ | VI | sea-sei-cna-hla-hlg-efb |
| Wound infection (284) | Singleton 4/2642, t064 | V | 1 | – | +/+ | IV | hla-hlg-efb |
| Wound infection (221) | 30/30, t012 | IV | 3 | + | +/+ | VI | sei-cna-hla-hlg-efb |
| Wound infection (27/231) | 30/503, t012 | IV | 3 | + | +/+ | VII | sei-cna-hla-hlg |
| Wound infection (296) | 22/22, t005 | IV | 1 | + | +/+ | I | sec-sei-cna-hla-hlg |
| Wound infection (293) | 22/1414, t1328 | IV | 1 | + | +/+ | I | sei-cna-hla-hlg |
| Wound infection (UC104) | 22/22, Unk | IV | 1 | + | +/+ | II | sei-cna-hla-hlg-efb |
| Wound infection (UC101) | 22/22, t091 | +/+ | |||||
| Wound infection (UC463) | 22/22, t309 | IV | 1 | + | −/− | III | sec-sei-cna-hla-hlg-efb |
| Wound infection (2518)∗ | 121/120, t272 | NT | + | +/+ | VI | sea-sei-cna-hla-hlg-efb | |
| MSSA (n = 77) | |||||||
| Wound infection (2130) | 772/772, t345 | 2 | + | +/+ | VI | sec-cna-hla-hlg-efb | |
| Wound infection (2164) | 772/772, t1839 | UT∗ | None | + | +/+ | VI | sea-sec-sei-cna-hla-hlg-efb |
| Wound infection (2493) | 772/1, t386 | 4 | + | +/+ | VI | sei-cna-hla-hlg-efb | |
| Eye infection (N309852) | 772/1, t098 | 3 | – | +/+ | VII | sea-cna-hla-hlg | |
| Eye infection (518) | 772/1, t693 | UT∗ | 3 | – | +/+ | VII | sea-sei-cna-hla-hlg-efb |
| Eye infection (535,1636) | 772/1, t127 | UT∗ | 3 | – | +/+ | VII | sea-sei-cna-hlg-efb |
| +/+ | V | ||||||
| Eye infection (831) | 772/1, t127 | UT∗ | 3 | – | +/+ | II | sea-sei-cna-hla-hlg-efb |
| Eye infection (1361) | 772/1, t128 | UT∗ | 3 | – | +/+ | VII | sea-sec-sei-hla-hlg-efb |
| Eye infection (1321) | 772/1, t177 | UT∗ | 3 | – | +/+ | VII | sea-sei-cna-hla-hlg-efb |
| Eye infection (1476) | 772/1, t127 | 3 | – | +/+ | VIII | sea-sei-cna-hla-hlg-efb | |
| Eye infection (1881) | +/+ | I | |||||
| Eye infection (1503) | 772/1, t127 | 3 | – | +/+ | VI | sei-cna-hla-hlg-efb | |
| Eye infection (975) | 772/1, t8078 | 3 | – | +/+ | VI | sei-hla-hlg-efb | |
| Eye infection (1214) | 772/772, t657 | 3 | + | +/+ | VI | sea-sec-sei-cna-hla-hlg | |
| Healthy conjunctiva (N11OD) | 772/1, t948 | UT∗ | None | – | +/+ | I | sea-sei-cna-hla-hlg-efb |
| Healthy conjunctiva (N12OD) | 772/1, t948 | 3 | – | +/+ | IV | sea-cna-hla-hlg-efb | |
| Wound infection (2151) | 30/714, t021 | 3 | + | +/+ | VI | sei-cna-hla-hlg-efb | |
| Wound infection (2413) | 30/1482, t386 | 3 | + | +/+ | IV | sei-cna-hla-hlg-efb | |
| Eye infection (1196) | 30/938, t021 | 3 | + | +/+ | IV | sei-cna-hla-hlg-efb | |
| Eye infection (1850) | +/+ | V | |||||
| Wound infection (2488) | 121/121, t159 | 4 | – | +/+ | II | sei-cna-hla-hlg-efb | |
| Eye infection (P832812) | 121/121, t3204 | 4 | + | +/+ | V | cna-hla-hlg | |
| Eye infection (P706434) | 121/1964, t272 | 4 | – | +/+ | V | sei-cna-hla-hlg | |
| Eye infection (917) | 121/2160, t159 | 4 | + | +/+ | V | cna-hla-hlg-efb | |
| Unknown (2657) | 2884/2884, t4104 | 3 | + | +/+ | III | hla-hlg-efb | |
| Eye infection (149) | 2884/88, t5562 | 3 | + | −/+ | VI | sei-hla-hlg-efb | |
| Eye infection (1764Y) | 2884/88, t448 | 3 | + | +/+ | VIII | sea-sei-hla-hlg-efb | |
| Eye infection (504, 1035, 1271) | 5/5, t442 | 2 | – | +/+ | II | sei-cna-hla-hlg-efb | |
| +/+ | sei-hla-hlg-efb | ||||||
| +/+ | sei-hlg | ||||||
| Eye infection (N303284) | None | – | +/+ | I | sei-cna-hla-hlg | ||
| Eye infection (843) | 2 | – | +/+ | VIII | sei-hlg-efb | ||
| Eye infection (1042) | 2 | – | +/+ | VII | sei-hla-hlg-efb | ||
| Eye infection (1766, 1862) | 1 | – | +/+ | VIII | sei-hla-hlg | ||
| +/+ | sei-hla-hlg-efb | ||||||
| Eye infection (1867) | 1 | – | +/+ | VII | sei-hla-hlg-efb | ||
| Eye infection (1103) | 5/5, t14912 | 2 | – | +/+ | V | sei-hla-hlg-efb | |
| Eye infection (1306) | 5/83, t442 | 2 | – | +/+ | II | sei-hla-hlg-efb | |
| Eye infection (1424) | 5/5, 8179 | 2 | – | −/ + | VI | sei-hla-hlg-efb | |
| Healthy conjunctiva (N9OD) | 5/5, t010 | 2 | – | +/+ | VII | sei-hla-hlg-efb | |
| Wound infection (17/201) | 813/813, t10579 | 1 | – | +/+ | VII | sei-cna-hla-hlg | |
| Wound infection (262) | 813/291, t1149 | 1 | – | +/+ | VII | hlg | |
| Eye infection (186) | 22/22, t310 | 1 | + | +/+ | II | sei-cna-hla-hlg-efb | |
| Healthy conjunctiva (N61OD) | 22/22, t948 | UT∗ | 1 | + | +/+ | VII | sea-sei-hla-hlg-efb |
| Eye infection (481) | Singleton 1/580, t14911 | None | – | −/ + | V | sei-cna-hla-hlg-efb | |
| Eye infection (N297214) | Singleton 2/45, t302 | 1 | – | +/+ | VII | cna-hla-hlg | |
| Wound infection (2417) | Singleton 3/Unk, t021 | None | – | −/− | VI | sei-hla-hlg-efb | |
| Eye infection (1525,1545) | Singleton 5/72, t148 | 1 | – | −/ + | VI | sei-hla-hlg | |
| None | – | −/ + | V | sei-cna-hla-hlg-efb | |||
| Wound infection (1/229, 861) | Singleton 6/789, t091 | 1 | – | −/− | III | sei-cna-hla-hlg | |
| None | – | +/+ | III | sei-cna-hla-hlg-efb | |||
| Wound infection (379) | Singleton 6/789, t2505 | None | – | +/+ | III | sei-cna-hla-hlg-efb | |
| Eye infection (1603) | Singleton 6/789, t091 | 1 | – | +/+ | V | sei-hla-hlg-efb | |
| Eye infection (1320) | Singleton 7/6, t657 | 1 | – | +/+ | III | sei-cna-hla-hlg-efb | |
| Eye infection (1428) | Singleton 7/6, t4285 | 1 | – | −/ + | VIII | sea-sei-cna-hla-hlg-efb | |
| Eye infection (1698) | Singleton 7/6, t12406 | 1 | – | +/+ | VIII | sea-sei-cna-hla-hlg-efb | |
| Healthy conjunctiva (N21OS) | Singleton 8/15, t084 | 2 | – | +/+ | IV | sei-hla-efb | |
| Wound infection (2508) | Singleton 9/2885, t15579 | 4 | + | +/+ | III | sei-cna-hla-hlg-efb | |
| Wound infection (2653) | Singleton 10/672, t3841 | 2 | – | ± | I | sei-hla-hlg-efb | |
| Eye infection (N259615, N289378, 1049, 1506) | Singleton 10/672, t3841 | 1 | – | +/+ | I | sei-cna-hla-hlg | |
| None | – | +/+ | I | cna-hla-hlg | |||
| 1 | – | +/+ | VII | sei-hla-hlg-efb | |||
| 1 | – | +/+ | VIII | sei-hla-hlg-efb | |||
| Eye infection (188, 1164, 1355, 1670) | Singleton 10/672, t1309 | I | – | +/+ | I | sei-hla-hlg-efb | |
| I | – | −/ + | II | sei-hla-hlg-efb | |||
| I | – | +/+ | I | sei-cna-hla-hlg-efb | |||
| 1 | – | +/+ | VIII | sei-cna-hla-hlg | |||
| Eye infection (884,1333) | Singleton 11/2233, t2663 | 3 | + | +/+ | VII | sei-cna-hlg-efb | |
| +/+ | |||||||
| Eye infection (1716OD, 1758) | 3 | + | +/+ | IV | sei-cna-hla-hlg | ||
| +/+ | |||||||
| Eye infection (1716OS, 1769) | 3 | + | −/+ | VIII | sei-cna-hla-hlg | ||
| 4 | +/+ | ||||||
| Eye infection (915, 1366, 1729) | 3 | + | +/+ | VII | sei-cna-hla-hlg-efb | ||
| UT∗ | 3 | + | −/+ | VII | sei-hla-hlg | ||
| 3 | – | +/+ | VIII | sea-sei-cna-hla-hlg-efb |
MRSA: methicillin-resistant Staphylococcus aureus; MSSA: methicillin-sensitive Staphylococcus aureus; CC: clonal complex; ST: sequence type; SSC: Staphylococcal cassette chromosome; agr: accessory gene regulator; Unk: unknown; UT: untypeable; NT: non-typeable; ∗Isolates with ccrAIB1 complex but lack mec complex; pvl: Panton-valentine leucocidin; icaA: intracellular adhesion gene A; icaD: intracellular adhesion gene D; sea: staphylococcal enterotoxin A; sec: staphylococcal enterotoxin C; sei: staphylococcal enterotoxin I; cna: collagen adhesion; hlyA: hemolysin A; hlyG: hemolysin G; efb: extracellular fibronectin binding protein.