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. 2019 Dec 4;10:2850. doi: 10.3389/fimmu.2019.02850

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Copyright © 2019 Tao, Tao, Busch, Widera, Schaal and Drexler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Presentation of viral late antigens to CTL is impaired. (A) qRT-PCR. Gene expression profile for B22, I1, A6, and H3 in BMDC infected with MVA-wt (MOI 10) from 0 to 6 h post infection (h p.i.). (B) Kinetic analysis of IFNg production [4 h intracellular cytokine staining (ICS)] by HLA-A2.1-restricted HHD-derived CD8+ T cell lines with the indicated epitope-specificities after stimulation with MVA-infected HLA-A2.1+ BMDC (MOI = 10) derived from HHD mice. The presentation of all late antigens tested (I1, A6, and H3) allowed for the activation of the respective CTL lines with a strong delay compared to CTL specific for early antigen B22. All data are means and SEM (n ≥ 3) from three independent experiments.