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. 2019 Mar 18;142(4):1024–1034. doi: 10.1093/brain/awz034

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Relationship between network topology and neurocognitive reserve. (A) Relationship between cartographic profile (Parkinson’s disease OFF > Parkinson’s disease ON) and interaction between grey matter volume and education level (NART). FDR q ≤ 0.05. Subjects with greater NART and grey matter scores were more integrated (i.e. rightward shift on the B_T axis) in the OFF compared to the ON state. (B) Regions with significant relationship between B_T (OFF > ON) and the interactions between brain (mean grey matter) and cognitive (NART) reserve, estimated using a linear mixed effects model. FDR q ≤ 0.05. GLM = general linear model.