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. 2018 Mar 23;218(1):35–43. doi: 10.1093/infdis/jiy170

Figure 1.

Figure 1.

Human vaccine-induced and naturally acquired IgG subclass and IgM antibodies to MSP2. A, IgG subclasses (IgG1–IgG4) were assessed in sera from MSP2-C1 vaccine recipients prior to vaccination (day 0) and at day 112 postvaccination (peak response) against MSP2 3D7 (left) and FC27 (right) alleles. B, Naturally acquired IgG subclass responses to MSP2. Samples were obtained from malaria-exposed children residing in Papua New Guinea (ages 5–14, n = 206) [24]. C, IgM responses were measured in samples from MSP2-C1 vaccine (n = 29) and placebo (n = 6) recipients prior to vaccination (day 0, white boxes) and postvaccination (day 112, grey boxes) against both 3D7 and FC27 alleles. There was a significant increase in IgM responses against both alleles in vaccine recipients, but no difference was observed between day 0 and day 112 with the placebo controls. P values were calculated using the Wilcoxon matched-pairs signed rank test for the comparison between day 0 and day 112 samples.