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. 2019 Dec 4;10:2797. doi: 10.3389/fimmu.2019.02797

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Copyright © 2019 Wang, Zhu and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression and effect of SESN2 on immune cells. SESN2 has been found to be expressed in multiple immune cells such as monocytes, macrophages, NK cells, and T lymphocytes. The expression of SESN2 exerts a beneficial effect on the function of immune cells through activating AMPK, inhibiting mTORC1 signaling, suppressing JNK pathway activation, or alleviating the prolonged activation of NLRP3 inflammasome.