Figure 1.

Venn diagram displaying the variations among dosage-sensitive gene data sets obtained through different methods. The 853 dosage-sensitive genes shared by the four data sets obtained by Makino et al. (2013); Lek et al. (2016); Shihab et al. (2017), and Rice and McLysaght (2017b)were regarded as the most reliable dosage-sensitive (MRDS) genes. To obtain a data set of the most reliable dosage-insensitive (MRDIS) genes, the 9,459 genes that were absent from any of the four data sets were further filtered by discarding the genes with a pLI value > 0.5 in either the data set of Shihab et al. (2017)or the data set of Lek et al. (2016). In total, 5,579 MRDIS genes were obtained.