Table 6.

Comparison of selective pressures.

	Number of genes	d N/d S± SD	p
MRDS genes	853	0.062 ± 0.057	<10−6
MRDIS genes	4188	0.257 ± 1.536
MRDS TFs	122	0.066 ± 0.054	<10−6
MRDIS Fs	226	0.256 ± 0.217
TFs	1374	0.134 ± 0.141	<10−6
Other genes	16804	0.161 ± 0.776

The most reliable dosage-sensitive (MRDS) genes and the most reliable dosage-insensitive (MRDIS) genes are defined in Tables 1 and 2 as well as in the main text. The p values were calculated using Mann-Whitney U tests.