Table 6.
Results of liver or combined liver and kidney transplantation in seven children with CFH mutations. Pre- and intra-operative intensive plasmatherapy appear as a prerequisite for success. PTLD post-transplant lymphoproliferative disease
Authors (reference) | Age of patient (years) | CFH mutation | Transplantation | Plasmatherapy | Post-operative anticoagulation | Outcome (follow-up) | |
---|---|---|---|---|---|---|---|
Pre-operative | Per-operative | ||||||
Remuzzi et al. [68] | 2 | W 1183 R | Liver + kidney | No | No | No | Liver failure at day 26; re-transplantation neurologic sequels |
SCR 20 | |||||||
Cheong et al. [69] | 2.5 | C926 F | Auxiliary liver | No | No | No | Death at 10 months from infections and PTLD |
SCR 15 | |||||||
Remuzzi et al. [70] | 2 | E 1172 stop | Liver + kidney | No | No | No | Primary non-function of liver, thrombotic/ischemic lesions, post-operative death) |
SCR 20 | |||||||
Saland et al. ([71] and personal communication) | 2.2 | C 973 Y, SCR 15, V 1197 A, SCR 20 | Liver + kidney | PE 50 ml/kg | FFP 19 ml/kg | Yes | Both grafts successful (4 years) |
4 | S 1191 L, SCR 20 | Liver + kidney | Idem | Idem | Yes | Both grafts successful (1.5 years) | |
Jalanko et al. [72] | 1.6 | R 1215 Q | Liver + kidney | PE 98 ml/kg | FFP 36 ml/kg | Yes | Both grafts successful (15 months) |
SCR 20 | |||||||
16 | R 1215 Q | Liver + kidney | PE 52 ml/kg at H-12 and 86 ml/kg pre-op | PE 70 ml/kg | Yes | Both grafts successful (8 months) | |
SCR 20 |