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. 2007 Jun 1;22(6):788–797. doi: 10.1007/s00467-006-0390-1

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© IPNA 2007

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Fig. 3 — Dynamics of the kidney and ureteral development according to the “bud theory”. Relationship between ureteric bud position on the Wolffian duct to the nephrogenic blastema and orifice positions in the bladder and urethra. A Ectopic bud orifice on the lateral and cranial end of the extended hemitrigone (site a), resulting in VUR. B Normal ureteric bud orifice B on the corner (site b). C Ectopic bud orifice on the caudal extremity of the bladder. The metanephric mesenchyme is well differentiated when interacting with a bud at the normal site B but sparse and poorly differentiated around bud A and C (from [4])