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. 2007 Oct 1;22(10):1659–1673. doi: 10.1007/s00467-007-0482-6

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© IPNA 2007

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Fig. 4 — Urine calcium excretion in genetic hypercalciuric stone-forming (GHS) and control (Ctl) rats. Alendronate led to a significant decrease in urine calcium in the GHS, but not in the Ctl rats. GHS rats (open symbols), Ctl rats (closed symbols), NCD normal-calcium diet (1.2% calcium, triangles), LCD low-calcium diet (0.02% calcium, squares), LCD + Aln alendronate (Aln, 50 g/kg per 24 h, circles). Used with permission [106]