Figure 3.

The added value of adding one platinum resistance targeting drug to platinum-taxane treatment. The waffle plots illustrate the fraction of sensitive, partially, and fully resistant cells in tumors. Black circles represent tumor burden after primary treatment relative to the tumor burden after platinum-based chemotherapy alone. The number below the waffle plots is the median PFI. Kaplan-Meier plots of PFI for each combination therapy (red line) compared to chemotherapy alone (blue line). The graphs were compared using log-rank test. Adding Wee1 inhibitor to platinum-based chemotherapy results in a PFI of 26 months, which is 19 months more than with the SOC. Furthermore, after adding Wee1 inhibitor, the residual tumor contains a sizable fraction of platinum-sensitive cells, which increases the probability of a successful platinum rechallenge in the subsequent treatment cycles. All two- and three-drug combination results are shown in Supplementary Fig. 3.