Table 1.

Standard parameters and their values for the platinum resistance mathematical model. “—” represents dimensionless unit.

Symbol	Value	Unit	Description	Reference
b	0.667	$\frac{1}{\mathrm{day}}$	Division rate	Taken from27
d	0.661	$\frac{1}{\mathrm{day}}$	Death rate	Taken from29
u	10−5	$\frac{1}{\mathrm{cell}\mathrm{division}}$	Transition rate	Taken from5
M	3.959·1011	# of cells	Average tumor burden at diagnosis	Taken from5
Mrelapse	109	# of cells	Tumor burden at recurrence	Taken from30
dchemotherapy	0.856	—	Average chemotherapy effect on sensitive cells	Estimated from a calibration cohort from5
α1	0.02	—	Weight of chemotherapy effects on cells with one resistance mechanism	Estimated from a calibration cohort from5
α2	0.01	—	Weight of chemotherapy effects on cells with two resistance mechanisms	Estimated from a calibration cohort from5
β	2	cell-log kill	Fraction of cells removed by surgery	Taken from5