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. 2019 Dec 10;10:5640. doi: 10.1038/s41467-019-13555-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a 2D density plot of the methylation level of orthologous TEs (n = 140,185 TEs) in seven anatomy-matched human-mouse epigenome pairs. TE pairs missing methylation in either epigenome or lacking CpGs are excluded. b Methylation state of orthologous TEs in human and mouse across the seven epigenome pairs. Percentages to the right of each x-axis state indicate the proportion of TE ortholog instances across the epigenome pairs that are annotated with that state. c chromHMM state of orthologous TEs (n = 296,457 TEs) in human and mouse across twelve anatomy-matched epigenome pairs. Percentages to the right of each x-axis state indicate the proportion of TE ortholog instances across the epigenome pairs that are annotated with that state. d Tissue-specificity profiles in mouse for orthologous TEs that exhibit tissue specificity in that tissue in human. TEs are considered tissue-specific if they are annotated with a state in two epigenomes from the same tissue but fewer than 5 epigenomes overall. Active: any active regulatory state (Brain n = 1,812 TEs, Intestine n = 1,691, Stomach n = 205, Heart n = 3,081, Lung n = 653); Promoter: 1_TssA/TssA (Brain n = 54 TEs, Intestine n = 27, Stomach n = 16, Heart n = 49, Lung n = 16). TEs in the 2–8 epigenomes category are not specific to the tissue.