Table 1.

Allostatic load biomarker cutpoints

Biomarker	Guideline used	AL cutpoints	% Above cutpoint
Metabolic system
HDL (mg/dL)	ATPIII	<50	41.06
LDL (mg/dL)	ATPIII	≥100	52.17
Waist Circumference (in)	ATPIII	>35	72.46
Glucose (mg/dL)	ATPIII	≥100	17.39
HbA1c (mmol/mol)	ADA	≥5.7	19.32
Total Cholesterol (mg/dL)	ATPIII	≥160	66.18
Triglycerides (mg/dL)	ATPIII	≥150	7.25
BMI (kg/m2)	ATPIII	≥85.51
Cardiovascular system
Systolic BP (mm Hg)	AHA	≥120	47.34
Diastolic BP (mm Hg)	AHA	≥80	47.83
Neuroendocrine system
Cortisol (μg/dL) a	n/a	>12.69	25.12
Epinephrine (pg/mL) a	n/a	>77.70	24.15
Norepinephrine (pg/mL) a	n/a	>686.30	25.12
Inflammatory system
IL-6 (pg/mL)a	n/a	>7.85	29.47
hsCRP (mg/L)	AHA	>3	49.28

Biomarker abbreviations: HDL = High-density lipoprotein; LDL = Low-density lipoprotein; HbA1c = Hemoglobic A1c (glycated hemoglobin); BMI = Body mass index; Systolic BP = Systolic blood pressure; Diastolic BP = Diastolic blood pressure; IL-6 = Interlukin 6. hsCRP = High-sensitivity C-reactive protein.

SI conversion factors: To convert HDL to mmol/L, multiply values by 0.0259; LDL to mmol/L, multiply values by 0.0259; glucose to mmol/L, multiply values by 0.0555; Total Cholesterol to mmol/L, multiply values by 0.0259; Triglycerides to mmol/L, multiply by 0.0113; Cortisol to nmol/L, multiply by 27.588; Epinephrine to pmol/L, multiply by 5.459; norepinephrine to pmol/L, multiply by 5.911; IL-6 mmol/L, multiply by 2.539 e¹³; hsCRP to nmol/L, multiply by 9.524.

^a75th percentile cutpoints used for biomarkers that don’t have established clinical guidelines.