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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: J Immunol. 2019 Nov 15;203(12):3216–3224. doi: 10.4049/jimmunol.1900059

Figure 5. PI3K activation is required for FcγR-mediated CD31 internalization.

Figure 5.

PBM were preincubated with inhibitors to block the listed signaling pathways, then incubated in control PBS-treated (UT, untreated) or immobilized IgG-coated wells for 4 hours. Mean fluorescence intensity (MFI) of CD31 surface expression was measured using flow cytometry. (A) U0126 (Meki) (n=6). (B) SB203580 (p38i) (n=6). (C) SP60025 (Jnki) (n=6). (D) LY294002 (PI3Ki) (n=5). * p ≤ 0.05 between stimulated and DMSO-control cells; ** p ≤ 0.01; *** p ≤ 0.001.