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. 2019 Dec 10;9:18727. doi: 10.1038/s41598-019-55199-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ITC measurements for the titration of SphK1 with (A) Quercetin and (B) Capsaicin. The upper panel shows the raw data points for heat produced with time with each titration of 750 µM of compound with 15 µM SphK1. The lower panel shows the binding isotherm obtained after integration of peak area and normalization to yield a plot of molar enthalpy change against each compound/SphK1 ratio. The fit curve is shown in red color line.