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. 2019 Dec 10;9:18756. doi: 10.1038/s41598-019-55128-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DT-induced focal aganglionosis does not affect total GI transit and colonic motility. A radiologic-based transit assay (a,a’) was used to measure solid and liquid transit following DT injection. No difference was observed in solid transit at 2 and 4 weeks after DT injection (b). Liquid transit showed a delay at 2 weeks, but not at 4 weeks (c). Ex vivo analysis by spatiotemporal mapping of the DT-injected colon from Wnt1-iDTR mice showed no changes in CMMC frequency (d), length (e), or velocity (f), as compared to controls.