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. 2019 Dec 10;9:18756. doi: 10.1038/s41598-019-55128-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ENCDC transplantation reverses the effects of DT-induced aganglionosis on colonic architecture. Representative images are shown of H&E stained colon 4–5 weeks following DT injection into control (a), non-transplanted Wnt1-iDTR (a’), and ENCDC-transplanted Wnt1-iDTR (a”) mice. MCHI scores show low-grade inflammation in all three groups (b), with transplanted colon showing significantly less inflammation. DT-mediated ENS ablation leads to increased thickness of muscularis mucosa (MM) and longitudinal muscle (LM), with no significant change in circular muscle (CM), and these changes are reversed following cell transplantation (c). DT-mediated ENS ablation also increases mucosal thickness, which is partially normalized by ENCDC transplantation (d). Alcian blue staining (e,e’) shows no change in goblet cell size (f) or density (g) among the groups. Scale bar 100 µm (a-a”) and 50 µm (e,e’).