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. 2019 Dec 10;9:18759. doi: 10.1038/s41598-019-55371-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phosphorylated Panx3 at Ser68 is localized on the ER membrane. (A,a) Cellular localization of P-Panx3 in cells stably transfected with pEF1, pEF1/Panx3, or Ser68Ala. Fluorescent confocal images showed Panx3 (red), P-Panx3 (green), ER-tracker (cyan), and Hoechst nuclear staining (blue). (b) Measurements show a percentage of colocalization between P-Panx3 with ER-tracker. (B) Immuno-TEM demonstrates P-Panx3 localization on the ER membrane in pEF1/Panx3 transfected cells (right panel). M: mitochondria, ER: endoplasmic reticulum. The micrographs shown are representative of 15–20 cells obtained from three independent experiments. *P < 0.01. NS, nonsignificant. Error bars represent the mean ± SD; n = 12.