Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 10;9:18765. doi: 10.1038/s41598-019-55263-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The effects of AZM198 on cardiac remodeling and function. The effects of myeloperoxidase (MPO) inhibition by AZM198 on measures of cardiac function and remodeling in the obesity/hypertension model induced by high fat diet (HFD) and angiotensin II (AngII) infusion. Control animals received low fat diet (LFD). (A) Quantification of left ventricular ejection fraction (LVEF) as determined by cardiac magnetic resonance imaging (CMR). (B) Left ventricular (LV) weight corrected by tibia length to the power of 3. (C) Quantification of LV cardiomyocyte cross sectional area (CSA) from WGA-FITC stained mid-ventricular sections. (D) Lung weight corrected by tibia length to the power of 3. (E) Relative mRNA expression of LV genes, including natriuretic peptide precursor type A (NPPA), alpha-1 type 1 collagen (Col1a1), alpha-3 type 1 collagen (Col3a1), galectin-3 (Gal-3), growth differentiation factor 15 (GDF-15) and pyruvate dehydrogenase kinase 4 (PDK4). (F) Representative images of Masson’s trichrome-stained mid-ventricular sections. Red bar = 2 mm. (G) Quantification of LV fibrosis from Masson’s trichrome-stained mid-ventricular sections. Gene expression values are corrected for 36B4 gene expression and presented as fold change. N = 10–12. Bars represent means. Error bars represent standard error of the mean. *P < 0.05 as compared to LFD.