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. 2019 Dec 10;9:18689. doi: 10.1038/s41598-019-55150-6

Table 3.

Relative risk for overall survival of 22,458 patients.

Unadjusted RR (95% CI) P-value Adjusted RR (95% CI) P-value
Age
    <30 vs. 40–49 0.921 (0.904–0.939) <0.0001 0.890 (0.907–0.875) <0.0001
    <30 vs. 50–59 0.837 (0.816–0.861) <0.0001 0.827 (0.806–0.849) <0.0001
    <30 vs. 60–69 0.812 (0.774–0.853) <0.0001 0.821 (0.784–0.861) <0.0001
    <30 vs. ≥70 0.773 (0.695–858) <0.0001 0.779 (0.702–0.864) <0.0001
Sex (female vs. male) 0.802 (0.787–0.818) <0.0001 0.907 (0.888–0.925) <0.0001
Anticoagulation (non-user vs. user) 1.072 (1.009–1.139) 0.024 0.957 (0.983–1.044) 0.159
COPD (absence vs. presence) 0.888 (0.858–0.918) <0.0001 0.988 (0.955–1.779) 0.465
Brain metastasis (presence vs. absence) 1.089 (1.125–1.053) <0.0001 1.250 (1.208–1.294) <0.0001
First-line systemic treatment (TT vs. CC) 0.669 (0.653–0.686) <0.0001 0.686 (0.668–0.704) <0.0001

Abbreviations: RR, relative risk; CI, confidence interval; CC, cytotoxic chemotherapy; TT, targeted therapy; COPD, chronic obstructive pulmonary disease.