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. 2019 Dec 10;10(12):945. doi: 10.1038/s41419-019-2176-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MTT assay was performed in si-circ_0001955#1-transfected and si-circ_0001955#2-transfected (a) HepG2 and (b) SMMC-7721 cells, as well as in Lv-circ_0001955-transfected (c) Huh-7 and (d) Hep-3B cells, *P < 0.05. e–g The effect of circ_0001955 knockdown on HepG2 and SMMC-7721 cells was evaluated by colony formation assay, *P < 0.05. h–j The effect of circ_0001955 overexpression on Huh-7 and Hep-3B cells was examined by colony formation assay, *P < 0.05. k–m SMMC-7721 cells stably transfected with Lv-sh-NC and Lv-sh-circ_0001955 were subcutaneously injected into nude mice followed by examination of tumor volume and weight, **P < 0.01.