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. 2019 Dec 10;9:18695. doi: 10.1038/s41598-019-55145-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DRD2 mRNA expression in breast cancer cell lines. (A) Total RNA was harvested from a panel of 11 breast cancer cell lines, cDNA was made and DRD2 mRNA abundance was measured by qPCR. Graph depicts the average DRD2 expression normalized to GUSB for each cell line, relative to MCF7 cells. (B) The average expression of each basal-like and non-basal-like cell line is shown. (C) The average DRD2 mRNA expression is shown for each basal-like (gray) and non-basal-like cell line (black) is shown in relation to the effect of 2 µM thioridazine on tumorsphere formation for each cell line. A linear regression was performed to find the line of best fit. Curved lines represent the 95% confidence interval, and the p-value is the likelihood that the slope in non-zero. All experiments were perfomed with biological triplicates. Error bars fpr (B) represent standard deviation. Significance for (B) was measured using a two-sample t-test. **p < 0.01.