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. 2019 Dec 10;9:18707. doi: 10.1038/s41598-019-55019-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Placental T1 relaxation time estimates decrease following injection of liposomal-gadolinium contrast agent. Post-contrast T1 values are significantly lower than pre-contrast T1 values (p < 0.0005). Pre-contrast T1 values decreased as gestation progressed from E14.5 to E18.5. Post-contrast T1 values in the placenta were significantly lower at E18.5 than at E16.5. T1 relaxation times are reported in milliseconds (ms). Significance as determined by the Wilcoxon rank sum test are shown for p < 0.05 (one asterisk), p < 0.005 (two asterisks), and p < 0.0005 (three asterisks).