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. 2019 Dec 10;9:18707. doi: 10.1038/s41598-019-55019-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Placental fractional blood volume (FBV) estimated from nanoparticle contrast-enhanced MRI (CE-MRI) shows close agreement with values estimated by nanoparticle contrast-enhanced computed tomography (CE-CT). Box-and-whisker plots shown for (a) E14.5, (b) E16.5, and (c) E18.5 demonstrate mean placental FBV (horizontal lines) and standard deviation (vertical lines) along with any outliers (·) for CT (red) and MRI (blue). Bland-Altman plots showing the percent difference between MRI and CT estimates of FBV for each individual placenta are also shown for (d) E14.5, (e) E16.5, and (f) E18.5. Percent difference measurements for each individual FPU are represented (blue dots) along with the 95% confidence interval (red lines).