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. 2019 Dec 10;9:18762. doi: 10.1038/s41598-019-55041-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the reconstruction process used for the genome-scale metabolic network of Bacillus megaterium DSM319. (a) Based on genome alignment, 734 reactions of iMZ1055 were included in the reconstruction of the initial draft network. (b) The initial draft network was modified by performing several manual curation steps, utilization of Bacillus species GenBank genomes for multiple-alignment and further addition of relevant reactions to the model, and refining the model based on phenotyping data. Solid arrows represent the process direction and dotted lines relate to the operations that were performed based on the available data in public databases. “167 Reactions”, “174 Reactions” and “358 Reactions” refer to “the reactions that had at least one associated gene in COM and at least one associated gene in BMW”, “the reactions that were associated with some gene(s) of COM” and “the similar reactions that were present in the other four Bacillus GEMs”, respectively (see Supplementary Information).