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. 2019 Dec 10;9:18762. doi: 10.1038/s41598-019-55041-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Features of iJA1121, (a) distribution of iJA1121 and iMZ1055 reactions in different subsystems, (b) classification of reactions in iJA1121 based on the modifications, (c) modifications made to the draft network ranked in different subsystems. “No-change” refers to those reactions that were added directly from iMZ1055 based on homology. “Changed” represents those reactions that were added from iMZ1055 based on homology, but with alterations in their GPR associations, EC numbers and/or reversibility-type. “New” refers to those reactions which were newly added during the reconstruction process.