Table 1.
Correlation between genotypic and phenotypic evolution of chronic myelomonocytic leukemia in a 55 years old male patient.
| Date | Feb/2006 | Feb/2011 | Feb/2016 | Aug/2016 | Mar/2017 | |
|---|---|---|---|---|---|---|
| Parameters | Genotypic evolution | Normal values | ||||
| TET2%VAF | 44.58 | 38.50 | 46.72 | 45.54 | 46.15 | <5.0 |
| TET2%VAF | 39.06 | 39.39 | 48.72 | 49.48 | 49.19 | <5.0 |
| SRSF2%VAF | 37.44 | 39.33 | 44.28 | 48.74 | 49.38 | <5.0 |
| RUNX1%VAF | 46.83 | 48.69 | 47.77 | 48.98 | 48.60 | <5.0 |
| MPL%VAF | <5.0 | 40.93 | 48.58 | 48.25 | 50.50 | <5.0 |
| NRAS%VAF | <5.0 | <5.0 | 19.09 | 40.58 | 11.87 | <5.0 |
| IDH2%VAF | <5.0 | <5.0 | <5.0 | <5.0 | 35.42 | <5.0 |
| KRAS%VAF | <5.0 | <5.0 | <5.0 | <5.0 | 34.24 | <5.0 |
| RUNX1%VAF | <5.0 | <5.0 | <5.0 | <5.0 | 36.94 | <5.0 |
| U2AF1%VAF | <5.0 | <5.0 | <5.0 | <5.0 | 35.31 | <5.0 |
| Phenotypic evolution | ||||||
|---|---|---|---|---|---|---|
| WBC G/L | 3.1 | 8.5 | 16.6 | 24.6 | 19.3 | 4.4–11.3 |
| Hb g/dL | 14.3 | 10.5 | 11.2 | 10.2 | 10.9 | 14.0–17.5 |
| PLT G/L | 130 | 574 | 296 | 351 | 273 | 150–400 |
| Granulocytes% | 37 | 43 | 52 | 52 | 21 | 50–70 |
| Monocytes% | 18 | 47 | 16 | 11 | 4 | 2–9 |
| Blasts% | 0 | 0 | 1 | 10 | 66 | 0–0 |
| Spont. CFU-GM/105 PBMNC | ND | 8 | 170 | 381 | 116 | 3.5–8.5 |
Abbrevations: VAF, variant allele frequency; WBC, white blood cell count; Hb, hemoglobin; PLT, platelet count; CFU-GM, colony-forming unit-granulocyte-macrophage; PBMNC, peripheral blood mononuclear cells.