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. 2019 Dec 10;11:1759091419886212. doi: 10.1177/1759091419886212

Figure 2.

Figure 2.

BACHD mice present alterations in sciatic nerve morphology. (a and b) Representative images of transversal sections of the sciatic nerve from 12-month-old WT and BACHD mice, respectively. Note the difference between the size of the axons on inserts in (a; WT) and (b; BACHD). Scale bar: 10 μm. Quantification of nerve area (c), number of axons per nerve area (d), axon’s diameter (e; **p < .001; Mann–Whitney test), axoplasm diameter (***p < .0001; Mann–Whitney test; f), myelin thickness (g), G ratio (G = d/D, where G is the G ratio, d is the inner diameter, and D is the outer diameter; ****p < .0001; Mann–Whitney test; h). n = 3 animals per group. We analyzed 2.874 axons in WT and 2.573 in BACHD. Unpaired Student’s t test, p > .05 (c and d). WT = wild type.