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. 2019 Aug 27;27(12):2111–2122. doi: 10.1016/j.ymthe.2019.08.010

Figure 3.

Figure 3

Influence of 90-Day Anti-alpha-synuclein shRNA-MC RVG-Exosome Treatment on Alpha-Synuclein Aggregation

(A) Brain sections were stained for S129 phospho-synuclein, and the number of positive aggregates per section in the frontal cortex (F Ctx), somatosensory cortex (SS Ctx), somatomotor cortex (SM Ctx), striatum (St), amygdala (Amyg), and substatia nigra (SNc) were quantified. Typical immunohistochemical images of frontal cortex, striatum, and amygdala stained for S129 phospho-alpha-synuclein are shown. Data are expressed as mean ± SEM (n = 8). *p < 0.05, non-parametric Kruskal-Wallis test. (B) Immunofluorescent staining of midbrain sections with antibodies to S129 phospho-alpha-synuclein (green) and tyrosine hydroxylase (red). Magnified regions of the SNc are shown on the right; arrows indicate alpha-synuclein aggregates. Scale bars, 100 μm (left) and 10 μm (right).