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. 2019 Aug 27;27(12):2111–2122. doi: 10.1016/j.ymthe.2019.08.010

Figure 4.

Figure 4

Effect of 90-Day Anti-alpha-synuclein shRNA-MC RVG-Exosome Treatment on Alpha-Synuclein mRNA and Protein

(A–D) Quantitation of alpha-synuclein (A and B) mRNA levels and (C and D) protein levels in the (A and C) ipsilateral and (B and D) contralateral midbrain (MB), striatum (St), and cortex (Ctx) from alpha-synuclein PFF-treated mice (PFF) after 90 days following anti-alpha-synuclein shRNA-MC RVG-exosome treatment (PFF + Syn MC). mRNA and protein levels were normalized to actin; typical western blots of the midbrain are shown. Data are expressed as mean ± SEM (n = 10). *p < 0.05; **p < 0.01; ***p < 0.001, one-way ANOVA, statistical analyses compared with control group.