Figure 5.

SMC1 Knockdown Inhibits Tumorigenesis

(A) Tumor volume following SMC1 knockdown in MUM2B cells (n = 6). Suppressive effects on tumor growth in mice treated with knockdown SMC1. *p < 0.05 compared with control. (B) Tumor weight on day 20 (n = 6). Knockdown of SMC1 expression results in tumor weight reduction. *p < 0.05 compared with control. (C and D) SMC1 expression levels in normal, colon cancer, and melanoma tissues. SMC1 was highly expressed in colon cancer and melanoma tissues compared with normal tissues. *p < 0.05. Scale bars, 50 μm. (E) Immunohistochemical staining of SMC1 in tumor and normal tissues. SMC1 expression in tumor sections from six melanoma patients, six colon cancer patients, and six gastric cancer patients were higher than normal tissues (original magnification ×200).