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. 2019 Nov 14;105(6):1148–1167. doi: 10.1016/j.ajhg.2019.10.007

Figure 3.

Figure 3

Characterization of the Sperm Morphological and Ultra-structural Phenotype of Ttc29−/− L5 and L7 Mutant Mice

(A) Papanicolaou staining of epididymal sperm from Ttc29−/− L5 and L7 mutant mice, showing the presence of morphological abnormalities (black arrows) such as flagella bending, flagella of irregular caliber, and midpiece-principal piece disjunction as compared with control sperm (WT). Scale bars represent 10 μm.

(B) TEM analysis of epididymal sperm from Ttc29−/− L5 and L7 mutant mice, showing abnormal cross sections of the axoneme with ectopic peripheral doublets, lack of the central pair, and global disorganization of the structure as compared to control sperm with (9+2) canonical structure (WT). Scale bars represent 100 nm.