Table 1.
Top SNPs Identified from UK Biobank G × E Analyses
| Environ. Factor | Phenotype | RSID | CHR | Imputation Info | MAF | p Value (G effect)∗ | p Value (SPAGE) | p Value (Firth) | p Value (Wald) | Func.refGene | Gene.refGene |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Smoking status | chronic airway obstruction | rs55781567 | chr15 | 1 | 0.3343 | 7.76E-12 | 2.87E-08 | 2.55E-08 | 2.64E-08 | UTR5 | CHRNA5 |
| Gender | cardiac dysrhythmias | rs1906609 | chr4 | 0.99 | 0.1612 | 3.06E-68 | 1.42E-12 | 9.12E-13 | 1.11E-12 | intergenic | PITX2; C4orf32 |
| Vigorous physical activity | hyperlipidemia | rs10950866 | chr7 | 0.99 | 0.4230 | 0.2568 | 3.64E-09 | 3.82E-09 | 3.75E-09 | intronic | DNAH11 |
∗
p value of the marginal genetic effect